Health

Danger Abounds When Meds and Your Genes Don’t Mix

Danger Abounds When Meds and Your Genes Don’t Mix

Karen Daggett, Frazee, MN.

Mary Relling, PharmD, chair, pharmaceutical sciences, St. Jude Children’s Research Hospital; workforce chief, Clinical Pharmacogenetics Implementation Consortium.

Jennifer Hockings, PhD, PharmD, pharmacogenomics scientific specialist, Genomic Medicine Institute, Cleveland Clinic.

Tracy Glauser, MD, co-director, Genetic Pharmacology Service, Cincinnati Children’s Hospital.

The Journal of Molecular Diagnostics: “Preemptive Pharmacogenomic Testing for Precision Medicine: A Comprehensive Analysis of Five Actionable Pharmacogenomic Genes Using Next-Generation DNA Sequencing and a Customized CYP2D6 Genotyping Cascade.”

FDA.gov: “Table of pharmacogenomics biomarkers in drug labeling.”

Office of Disease Prevention and Health Promotion: “Adverse drug events.”

Stanford University: “Understanding genetics.”

University of Utah: “Observable human characteristics.”

National Library of Medicine, Genetics Home Reference.

Medical Genetics Summaries: “Tamoxifen therapy and CYP2D6 genotype.”

PharmGKB: “Very important pharmacogene: HLA-B.”

Mayo Clinic: “Stevens-Johnson Syndrome.”

F1000 Research: “Toxic epidermal necrolysis.”

Frontiers in Genetics: “HLA-B allele and haplotype diversity among Thai patients identified by PCR-SSOP: evidence for high risk of drug-induced hypersensitivity.”

Clinical Pharmacogenetics Implementation Consortium.

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